Fate of the thiomalate part after intramuscular administration of aurothiomalate in rheumatoid arthritis.
نویسندگان
چکیده
The excretory fate and plasma level of thiomalate were studied after intramuscular administration of auro-14C-thiomalate to 3 patients with rheumatoid arthritis. The gold and the thiomalate parts separated in vivo, and the free thiomalate was excreted in the urine, rapidly at first and then slowly. After one day about 60% of the 14C-label had been recovered in the urine. The plasma level also declined rapidly. The results are in complete agreement with those previously described in animal experiments.
منابع مشابه
Synovial fluid in antiquity.
7 Hall N D, Gillan A H. Effects of antirheumatic drugs on protein sulphydryl reactivity of human serum. J Pharm Pharmacol 1979; 31: 676-80. 8 Jellum E, Munthe E, Guldal G, Aaseth J. Fate of the gold and the thiomalate part after intramuscular administration of aurothiomalate to mice. Ann Rheum Dis 1980; 39: 155-8. 9 Munthe E, Guldal G, Jellum E. Increased intracellular glutathione during penici...
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ورودعنوان ژورنال:
- Annals of the rheumatic diseases
دوره 41 4 شماره
صفحات -
تاریخ انتشار 1982